A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin in a 2 Years Old Boy / 소아알레르기및호흡기학회지

Toxic epidermal necrolysis(TEN) is a severe drug induced life-threatening disease and an acute illness. This disease is characterized by rapid onset of widespread necrosis resulting in sloughing of epidermis. The incidence of TEN is very rare, with approximately 0.5 to 1.4 cases per million per year. but TEN has a high mortality rate of 25-40 percent. Therapy for TEN is primarily aimed at supportive care. Treatment with systemic corticosteroid, immunosuppresive agent such as cyclosporine, cyclophosphamide, pentoxifyllin or plasmapheresis have not been shown to improve outcome. Recently, administration of high dose intravenous immunoglobulin(IVIG) has been shown to result in rapid improvement in patients with TEN. There have been several reports of the benefit of IVIG in adult patients with TEN. However we could not find using IVIG in pediatric patient with TEN in Korea. We have experienced improvement in a 2 years old boy with TEN after using high dose IVIG.

A Case of Cutaneous Larva Migrans / 대한피부과학회지

A 30-year-old man presented with several intensely prurutic erythematous serpiginous thread-like skin lesions which began as a small papule on the upper back 2 weeks prior to his visit and was migrating to the lower back and buttock area. The laboratory examination showed non-specific findings. Histopathologic examination revealed a pustular burrow containing numerous eosinophils in the epidermis. In the dermis, there was a diffuse and occasionally dense perivascular inflammatory cell inflammation consisting of eosinophils and some lymphocytes. The patient was treated with oral albendazole, antihistamine and topical corticosteroid for 2 weeks without recurrence for 6 months up to now. Multiple histologic sections were made without success in demonstrating parasitic tissue in the epidermis, however, the clinical and histopathologic features were consistent with cutaneous larva migrans.